解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Hyperbaric oxygenation is known to affect energy metabolism and endothelial cell structure and function, but its effects on peripheral nerve have not been reported. We investigated whether it would (i) reverse established streptozotocin-induced diabetic neuropathy, a condition in which endoneurial hypoxia exists; (ii)...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90139-2
更新日期:1988-01-01 00:00:00
abstract::Systemic administration of kainic acid (12 mg/kg, i.p.), causing the established epileptic syndrome and the associated specific pattern of limbic nerve cell loss, led to substantial time-dependent increases in the brain metabolism of the endogenous excitotoxin, quinolinic acid. These changes preferentially affected bi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90140-9
更新日期:1988-01-01 00:00:00
abstract::Single-unit microelectrode studies were conducted to test the effects of systemic cocaine HCl on spontaneously firing single noradrenergic locus ceruleus (presynaptic) and cerebellar Purkinje (postsynaptic) neurons in rats in vivo. The spontaneous neuronal activity of all locus ceruleus neurons was inhibited by cocain...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90261-5
更新日期:1987-12-01 00:00:00
abstract::Fluorescence microscopy revealed that the innervation of the vasa nervorum of both cranial and spinal nerve roots in the subarachnoid space in the monkey is adrenergic in nature. The endoneurium of the cranial nerve roots contained free adrenergic nerve fibers which were not related to the vessel wall. ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90275-5
更新日期:1987-12-01 00:00:00
abstract::The claim that AlCl3 could produce 100% inhibition of cerebrospinal fluid secretion was investigated using ventriculocisternal perfusion in the rabbit, and it was shown that a large part of this inhibition was an artefact due to a pH sensitivity of Blue Dextran, used as an indiffusible marker, caused by AlCl3. Thus th...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90253-6
更新日期:1987-11-01 00:00:00
abstract::Exposure to low doses of gamma irradiation results in the modification of both the antinociceptive properties of morphine and the severity of naloxone-precipitated withdrawal in morphine-dependent rats. To better define the interactions between gamma irradiation and these opiate-mediated phenomena, dose-response studi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90244-5
更新日期:1987-11-01 00:00:00
abstract::In vivo studies have shown that high blood concentrations of pituitary-adrenocortical hormones can activate the hippocampal cholinergic terminals. Incubation of hippocampal synaptosomal preparations with methylprednisolone, or with ACTH at concentrations comparable to stress-induced high concentrations in plasma, did ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90078-1
更新日期:1987-10-01 00:00:00
abstract::Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90083-5
更新日期:1987-10-01 00:00:00
abstract::Prostaglandin and thromboxane levels increase in mammalian brain during seizures, but whether a metabolite of arachidonic acid has a role in induction, or is merely a by-product, of seizures is still not clear. It has been shown that nonsteroidal anti-inflammatory drugs block arachidonic acid metabolism through inhibi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90080-x
更新日期:1987-10-01 00:00:00
abstract::The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects on cortical association or heterosensory systems in alpha-chloralose-anesthetized cats. The drug depressed the anterior margi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90121-x
更新日期:1987-09-01 00:00:00
abstract::At the age of 31 days, Long-Evans female rats received electrolytic lesions either of the medial fimbria (N = 24), of the dorsal subcallosal fornix (N = 24), or of both structures (N = 24). Ten rats were used as sham-operated controls. Ten days later, half the rats of each lesion group received intrahippocampal grafts...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90114-2
更新日期:1987-09-01 00:00:00
abstract::Intercostal muscle tendon organs have an inhibitory effect on the medullary neurons driving all inspiratory muscles, and on a subpopulation of medullary bulbospinal expiratory neurons. Results from this study showed that the activity of expiratory related neurons in the region of the retrofacial nucleus (Botzinger com...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90129-4
更新日期:1987-09-01 00:00:00
abstract::The effects of unilateral intrahippocampal injection of kainic acid, a potent neuroexcitant and neurotoxin, on subsequent susceptibility to kindling of the contralateral hippocampus or contralateral amygdala were investigated in albino rats. At the chosen doses (0.20 to 1.25 micrograms dissolved in physiologic saline)...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90087-2
更新日期:1987-08-01 00:00:00
abstract::The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90098-7
更新日期:1987-08-01 00:00:00
abstract::Injections of horseradish peroxidase were made into surgically exposed superior cervical ganglia of Sprague-Dawley rats weighing 250 to 320 g. Anterogradely labeled postganglionic fibers were observed in the nervus conarii, pineal gland, pineal stalk, and the choroid plexus. Terminal fields were identified in lamina i...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90101-4
更新日期:1987-08-01 00:00:00
abstract::The EEG of 20 Wistar rats inbred for audiogenic seizures was recorded during 40 daily auditory stimuli 90 s long. The first stimuli provoked wild running, with no cortical EEG abnormality, and then a tonic phase with a characteristic EEG of a brief flat trace 2 to 3 s long followed by low-amplitude regular activity, 1...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90290-1
更新日期:1987-07-01 00:00:00
abstract::Hamsters were inoculated intracerebrally with the agent of transmissible mink encephalopathy and developed clerical signs of encephalopathy. Photoreceptor degeneration occurred in all animals examined histologically. The changes were similar to those in scrapie, although less extensive. The findings suggest that eithe...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90233-0
更新日期:1987-06-01 00:00:00
abstract::The antinociceptive properties of a new synthetic dipeptide (N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, or 5-HTP-DP-hex) were studied in rats by an electrophysiological method. After an i.p. injection of alpha-chloralose and urethane, the animals were prepared for stereotaxic approach to the nucleus ven...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90214-7
更新日期:1987-06-01 00:00:00
abstract::Unit activity related to a go/no-go visual discrimination task was studied in four rhesus monkeys. We recorded 272 task-related cells from frontal cortex in a region extending from the midprincipal sulcus to the central sulcus, and medially to the cingulate sulcus. Units located in anterior regions (dorsolateral prefr...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90213-5
更新日期:1987-06-01 00:00:00
abstract::It is clear that there are events which occur in response to neuromuscular activity that are essential to maintain normal muscle properties. Two factors though to influence muscle contractile properties are tension and electrical activity. To study these variables the hind limbs of 10 postpubertal female Sprague-Dawle...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90226-3
更新日期:1987-06-01 00:00:00
abstract::The dendritic organization of the phrenic nucleus as a whole was studied after injections of the B-subunit of cholera toxin conjugated to horseradish peroxidase were made into the diaphragm of adult rats. Transverse, sagittal, and horizontal sections through the phrenic nucleus (C3-C5) were incubated according to a mo...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90224-x
更新日期:1987-06-01 00:00:00
abstract::The aminergic and cholinergic fibers innervating the hippocampus reach their target regions via the dorsal (dorsal fornix, fimbria, and cingulum) and ventral routes. The plasticity of this innervation after lesions of the dorsal pathway was investigated in the septal, medial, and temporal regions of the adult rat hipp...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90053-7
更新日期:1987-05-01 00:00:00
abstract::An electron microscopic investigation of neuromuscular synapses of the tensor fasciae latae muscle in juvenile mice was carried out to determine the relationship between the presynaptic (nerve terminal) and postsynaptic (end-plate plaque) elements during the major phase of postnatal growth. In the first month of life ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90065-3
更新日期:1987-05-01 00:00:00
abstract::We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep....
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90179-8
更新日期:1987-04-01 00:00:00
abstract::Scopolamine and naloxone were administered singly and in combination to different groups of rats undergoing electrical kindling of the amygdala. Scopolamine significantly reduced the maximal seizure stage attained during 15 drug sessions and increased the total number of afterdischarges required to kindle a generalize...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90171-3
更新日期:1987-04-01 00:00:00
abstract::This study examined the effect of experimental diabetes on the anterograde and retrograde axonal transport of phosphofructokinase activity. Rats with streptozotocin-induced diabetes of 4 weeks duration showed phosphofructokinase activity accumulation deficits both proximal (53% and 65% in two separate experiments) and...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90180-4
更新日期:1987-04-01 00:00:00
abstract::Anatomic and electrophysiologic evidence suggests there is a vestibular input to eye movement-related pause neurons in the midline of the pontine reticular formation of the cat. The present investigation sought to explore the functional significance of this vestibular drive by examining pause neuron response to horizo...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90300-1
更新日期:1987-03-01 00:00:00
abstract::In 3-, 9-, 24-, and 30-month-old male rats (Fischer 344), the nuclear perimeter and the density and diameter of nuclear pore complexes in the granule cells of the dentate fascia were studied. Whereas the nuclear perimeter and the diameter of nuclear pore complexes did not change as a function of age, there was a signi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90314-1
更新日期:1987-03-01 00:00:00
abstract::Embryonic substantia nigra grafts partially reinnervate the dopamine-denervated corpus striatum when implanted adjacent to that structure. This reinnervation is generally limited to a small portion of the denervated striatum and does not completely compensate for the behavioral effects of a 6-hydroxydopamine lesion of...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90151-8
更新日期:1987-02-01 00:00:00
abstract::In birds, a variety of subtotal thoracic spinal cord lesions were made to determine the spinal cord pathways essential for avian hind limb locomotion (bipedal walking). The various surgical disruptions included: section of the dorsal half of the cord, a hemisection, section of the dorsal cord and ventromedial funiculi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90148-8
更新日期:1987-02-01 00:00:00
abstract::We recently described an experimental model of spinal cord contusive injury in the rat in which a modified weight-drop apparatus is used to generate reproducible mild, moderate, or severe final functional deficit. We now report several inexpensive alternatives for portions of the original apparatus which allow the pro...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90162-2
更新日期:1987-02-01 00:00:00
abstract::The question of whether or not the development of dystrophic muscles is similar to that of normal muscles, prior to the manifestations of the symptoms of the disease, is investigated here. The developmental change in the activity of succinate dehydrogenase was therefore measured in individual fibers of prospectively d...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90020-3
更新日期:1987-01-01 00:00:00
abstract::Twenty-eight-day-old (juvenile) rats were kindled with hourly stimulations to partial or fully kindled status. Adult rats were stimulated with hourly or daily stimulations. Alterations in [3H]dihydroalprenolol binding were determined 3 weeks after the last stimulation. We found that partially kindled, hourly stimulate...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90006-9
更新日期:1987-01-01 00:00:00
abstract::Chronic administration of cocaine (10 mg/kg, i.p., every 12 h for 10 consecutive days) produced a large decrease in tyrosine hydroxylase-staining axons and terminal boutons in the caudate nucleus in rats when examined 60 days after the final cocaine injection. This effect was quantitated using the Leitz data acquisiti...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90252-9
更新日期:1986-12-01 00:00:00
abstract::We investigated the involvement of central nervous system nicotinic-acetylcholine receptors in the secretory activity of the hypothalamic-hypophyseal-adrenal axis. Antiacetylcholine receptor antibodies derived from rabbits immunized with purified Torpedo-acetylcholine receptor or from myasthenia gravis patients were i...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90251-7
更新日期:1986-12-01 00:00:00
abstract::Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90229-3
更新日期:1986-12-01 00:00:00
abstract::Damage to the medial frontal cortex in rats results in a learning deficit on a reinforced alternation task. The rate of recovery from this deficit was accelerated by transplantation of either adult or embryonic frontal cortex, provided that a delay was introduced between injury and transplantation. The rates of recove...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90241-4
更新日期:1986-12-01 00:00:00
abstract::To determine if phenytoin reduces depolarization-linked acetylcholine release from synaptosomes solely by interacting with Na+, the effect of phenytoin (100 to 200 microM) and/or tetrodotoxin (1 microM) on ACh release was assayed in synaptosomes depolarized with either KCl 56 mM or veratridine 10 microM. Phenytoin red...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90255-4
更新日期:1986-12-01 00:00:00
abstract::Adult cats were subjected to subarachnoid hemorrhage by three repeated intracisternal injections of autogenous nonheparinized blood (2 ml/injection) at weekly intervals. Histological studies (light and electron microscope) were made of the basilar artery and the middle cerebral arteries of all animals. In the subarach...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90103-2
更新日期:1986-11-01 00:00:00
abstract::In the avian model of muscular dystrophy, electrophysiologic studies have shown alterations in the action potential characteristics of dystrophic muscle in vitro, supporting the notion that a membrane defect exists in avian dystrophy. As neurogenic and vascular etiologies have also been proposed, we examined the chara...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90114-7
更新日期:1986-11-01 00:00:00